منابع مشابه
c-kit+ Cardiac Stem Cells
One of the lingering controversies in the field of cardiac regenerative medicine has been around the origin of c-kit cardiac stem cells in the heart and their contribution toward cardiac homeostasis. A recent study reports that a subpopulation of c-kit cardiac progenitors emerges from the cardiac neural crest (CNC) with the capacity to give rise to cardiomyocytes. Contribution of CNC-derived c-...
متن کاملc-kit-Positive cardiac progenitor cells: the heart of stemness.
CIRCULATION RESEARCH (ISSN 0009-7330) is published semimonthly except one issue per month in November and December and three issues per month in March and August by Lippincott Williams & Wilkins, at 12107 Insurance Way, Hagerstown, MD 21740. Business offices are located at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, ...
متن کاملc-kit cardiac progenitor cells: what is their potential?
The very interesting paper by Tallini et al. (1) confirms our suggestion [derived from the study (2) of cardiospheres’ formation by cardiovascular precursors (CPs) isolated from the heart of embryonic, fetal, neonatal, and adult transgenic mice expressing GFP under the control of the c-kit promoter] that c-kit expression identifies in the heart CPs, differentiating into endothelial, cardiac, an...
متن کاملTranscription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells
Although transplantation of c-kit+ cardiac progenitor cells (CPCs) significantly alleviates post-myocardial infarction left ventricular dysfunction, generation of cardiomyocytes by exogenous CPCs in the recipient heart has often been limited. Inducing robust differentiation would be necessary for improving the efficacy of the regenerative cardiac cell therapy. We assessed the hypothesis that di...
متن کاملResident c-kit+ cells in the heart are not cardiac stem cells
Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for developing cell-based therapies for heart failure patients. Previously, cardiac c-kit(+) cells were reported to be CSCs with a potential to become myocardial, endothelial and smooth muscle cells in vitro and after cardiac injury. Here we provide further insights into the nature of cardiac c-kit(+) cells. By t...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2018
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.118.313215